Welcome to Ain Shams University

Center for Drug Discovery Research & Development

Vision

To be a Model Center for Drug Discovery and Development Research throughout the Middle East and Africa

Mission

Providing the required facilities and infrastructure required for performing a complete sophisticated research for drug discovery and development as well as the preparation of new generation of well-trained researchers in this field and providing different training and continuous education programs for students and young researchers.

Scientific Goals

1. Discovery and development of new entities from the different available natural resources including plants, Marine organisms and microorganisms.
2. Synthesis of new bioactive drug molecules ap­plying sophisticated computer aided drug design techniques.
3. Performing different research Studies (anticancer, anti­ inflammatory) with other centers
4. Providing continuous education facility through different workshops in the field of drug discovery and analysis for researchers in home or abroad.
5. Providing a fee-for-service services for the re­search communities including running different ex* pefimental procedures related to drug discovery and development field through the available facilities in the center.
6. Providing scientific consultations for the related bodies including ministry of health and population, drug companies and different research institutes working in drug discovery and development.
7. Exchange of experience through performing coo­peration agreements with similar research bodies inside ana abroad.
8. Providing training opportunities for undergradua­te students..

- Tissue Culture Lab. (not completed)
- LCMS Lab.
- NMRLab.
- Extraction and chromatography lab. Seminar and training hall.
- Secretary

SN

Title

Year

Authors

1.

Gastroprotective effects of Erythrina speciosa (Fabaceae) leaves cultivated in Egypt against ethanol-induced gastric ulcer in rats

2020

Nouran M. Fahmy, Eman Al-Sayed, Haidy E.

Michel, Mohamed El-Shazly, Abdel

Nasser B, Singab

2.

Caspicaiene: a new kaurene diterpene with anti- tubercular activity from an Aspergillus endophytic isolate in Gleditsia caspia desf

2020

Ashaimaa Y Moussa, Hagar A Sobhy, Omayma

A Eldahshan, Abdel Nasser B Singab

3.

Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model

2020

Mariam I Gamal El-Din, Fadia S Youssef, Riham

S Said, Mohamed L Ashour, Omayma A

Eldahshan, Abdel Nasser B Singab

4.

A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities

2020

Mohamed MM AbdelRazek, Ashaimaa Yehia

Moussa, Mohamed A El-Shanawany. Abdel

Nasser B Singab

5.

Two clerodane diterpenes isolated from Polyalthia longifolia leaves: comparative structural features, anti-histaminic and anti-Helicobacter pylori activities

2020

Martina P Edmond, Nada M Mostafa, Mohamed

El-Shazly, Abdel Nasser B Singab

6.

New y-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats

2020

Mariam I Gamal El-Din, Fadia S Youssef,

Mohamed L Ashour, Omayma A Eldahshan,

Abdel Nasser B Singab

7.

Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors

2020

Sayed K Ramadan, Eman Z Elrazaz, Khaled

AM Abouzid, Abeer M El-Naggar

8.

Isolation and Structure Elucidation of Compounds from Coccinia grandis Leaves Extract

2019

Somaia A. Al-Madhagy, Nada M. Mostafa 1,

Fadia S. Youssef, Ghada E. A. Awad. Omayma

A. Eldahshan, Abdel Nasser B. Singab

9.

New secondary metabolites from the mangrove- derived fungus Aspergillus sp. AV-2

2019

Ahmed M. Elissawy, Sherif S. Ebadaa,,

Mohamed L. Ashour, Mona El-Neketi,

Weaam Ebrahimd, AbdelNasser B. Singab

10.

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

2019

Nouran M. Fahmy, Eman Al-Sayed, Saad Moghannem,Faizul Azam, Mohamed El-Shazly, and Abdel Nasser Singab

11.

Pulchranin A: First report of isolation from an endophytic fungus and its inhibitory activity on cyclin dependent kinases

2019

Ashaimaa Y. Moussa, Nada M. Mostafa &

Abdel Nasser B. Singab

12.

Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

2019

Menna-Allah W Shalaby, Eman ME Dokla. Rabah AT Serya, Khaled AM Abouzid

13.

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

2019

Maiy Y Jaballah, Rabah AT Serya, Nasser Saad.

Sohair M Khojah, Marawan Ahmed, Khaled

Barakat, Khaled AM Abouzid

14.

Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity

2019

Nevine MY Elsayed, Rabah AT Serya, Mai F

Tolba, Marawan Ahmed, Khaled Barakat, Dalal

A Abou El Ella, Khaled AM Abouzid

15.

Identification of new pyrrole [2, 3-d] pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling

2018

Mai Adel, Rabah AT Serya, Deena S Lasheen,

Khaled AM Abouzid

16.

Surmounting the resistance against EGFR inhibitors through the development of thieno [2, 3-d] pyrimidine-based dual EGFR/HER2 inhibitors

2018

Sandra N Milik, Amal Kamal Abdel-Aziz, Deena S Lasheen, Rabah AT Serya, Saverio Minucci, Khaled AM Abouzid

17.

Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (FIDACi) and anticancer agents

2018

Heba M Hesham, Deena S Lasheen, Khaled

AM Abouzid

18.

Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity

2018

Monia Hossam. Deena S Lasheen, Nasser SM

Ismail, Ahmed Esmat, Ahmed M Mansour,

Abdel Nasser B Singab, Khaled AM Abouzid

19..

Study of the anti-allergic and antiinflammatory activity of Brachychiton rupestris and Brachychiton discolor leaves (Malvaceae) using in vitro models

2018

Amany A Thabet, Fadia S Youssef, Michal Korinek, Fang-Rong Chang, Yang-Chang Wu, Bing-Hung Chen, Mohamed El-Shazly. Abdel Nasser B Singab, Tsong-Long Hwang

20.

Spiroarthrinols a and B, two novel meroterpenoids isolated from the spongederived fungus Arthrinium sp

2017

Ahmed M Elissawy, Sherif S Ebada, Mohamed L Ashour, Ferhat C Ozkaya, Weaam Ebrahim, AbelNasser B Singab. Peter Proksch

21.

Phytochemical Investigation, Antitumor Activity, and Hepatoprotective Effects of Acrocarpus fraxinifolius Leaf Extract

2017

Heba AS ElNashar, Omayma A Eldahshan,

Omania E Elshawi, Abdel Nasser B Singab

22.

Anti-Inflammatory and Analgesic Activities of Tcrminalia Muelleri Benth. (Combretaceae)

2017

Nouran M Fahmy, Eman AlSayed, Mohamed M

AbdelDaim, Abdel Nasser Singab

23.

Hepatoprotective, Antihyperglycemic and Cytotoxic

Activities of Jacaranda acutifolia Leaf Extract

2017

NM Mostafa, OA Eldahshan, HA El-Beshbishy.

AN Singab

24.

Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics

2017

Fadia S Youssef, Rola M Labib, Omayma A

Eldahshan, Abdel Nasser B Singab

25.

Furo[2,3-d|pyrimidine based derivatives as kinase inhibitors and anticancer agents

2016

Marwa A Aziz, Rabah AT Serya, Deena S

Lasheen, Khaled AM Abouzid

26.

Cytotoxic Oleanane-Type Saponins from the Leaves of Albizia anthelmintica Brongn.

2016

Eman AID Sayed. Omayma A Eldahshan, Dina

M Bahgat, Abdel Nasser B Singab

27.

Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae)

2016

Nada M Mostafa, Mohamed L Ashour, Omayma

A Eldahshan, Abdel Nasser B Singab

28.

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

2016

Marwa A Aziz, Rabah AT Serya, Deena S Lasheen, Amal Kamal Abdel-Aziz, Ahmed Esmat, Ahmed M Mansour, Abdel Nasser B

Singab, Khaled AM Abouzid

29.

Synthesis and in vitro antiproliferative activity of novel pyrazolo [3, 4-d] pyrimidine derivatives

2015

Nermin S Abdou, Rabah AT Serya, Ahmed

Esmat, Mai F Tolba, Nasser SM Ismail, Khaled

AM Abouzid

30.

Bioactive Terpenes from Marine-Derived Fungi

2015

Ahmed M Elissawy, Mohamed El-Shazly, Sherif S Ebada, AbdelNasser B Singab, Peter Proksch

SN

Title of thesis

Year

Presented by

Faculty/ Univ.

Status

Finished/ running

1.

Comparative chemical study for the bioactive metabolites isolated from marine organisms and their associated fungi

2017

Ahmed

Elissawy

Pharmacy/Ain shams university

Finished /PhD

2.

Phytochemical and biological studies for some plants belonging to family Araliacae

2019

Naglaa

Mostafa

Pharmacy/Ain shams university

Finished/PhD

3.

Phytochemical and biological study on certain plants belonging to family Malvaceae

2020

Mariam

Ibrahim

Pharmacy/Ain shams university

Finished/PhD

4.

Phytochemical and biological studies for some plants belonging to family Fabacae

202

0

Nouran

Fahmy

Pharmacy/Ain shams university

Finished/PhD

5.

Phytochemical and biological studies for some plants belonging to family Anacardiaceae

202

0

Heba El-

Nashar

Pharmacy/Ain shams university

Finished/PhD

6.

Chemical and biological studies to some plants belonging to family Malvaceae

201

8

Amany

thabet

Pharmacy/Ain shams university

Finished/MSc

7.

Phytochemical and biological studies on Araucaria bediolia family Araucariaceae cultivated in Egypt

201

8

Aya

Talaat

Pharmacy/Ain shams university

Finished/MSc

8.

Phytochemical and biological studies on Spondias mangifera (Linh) Family Anacardiacae

202

0

Salma

Sameh

Pharmacy/Ain shams university

Finished/MSc

9.

Phytochemical and Biological studies on Brownea grandiceps belonging to family Fabacae

 

Doaa

Korany

Pharmacy/Ain shams university

Running/PhD

10.

Phytochemical and Biological study on Bontia daphnoids and Leucophyllum frutescens (Family Scrophulariacae)

 

Amany

Thabet

Pharmacy/Ain shams university

Running/PhD

11.

Phytochemical and Biological studies on plants belonging to genus Cestrum Family Solanacae

 

Dina

Bahgat

Pharmacy/Ain shams university

Running/PhD

12.

Phytochemical and biological study on Polyalthia longifolia Family Annonacae

 

Martina

Philip

Pharmacy/Ain shams university

Running/MSc.

13.

Bioactive secondary metabolites of Gelditsia caspica Family Fabacae

 

Hager

Ashraf

Pharmacy/Ain shams university

Running/MSc

14.

Phytochemical and biological studies on Polyalthia suberosa( Family Annonaceae) cultivated in Egypt

 

Orchid

Mahmoud

Pharmacy/Ain shams university

Running/MSc

15.

Phytochemical and biological studies on certain plants belonging to genus Erythrina (Family Fabaceae)

 

Ahmed

Mohsen

Pharmacy/Ain shams university

Running/MSc

16.

Chemical Investigation of endosyrnbiotic fungi isolated from selected marine invertebrates collected from the Red sea Egypt

 

Reem Helmy

Pharmacy/Ain shams university

Running/MSc

17.

Metabolic profiling of selected Iris species belonging to Family Iridaceae:Comparative study

 

Suzan

Mahmoud

Pharmacy/Ain shams university

Running/MSc

18.

Comparative study of the bioactive metabolites of Morus sp. roots cultivated in Egypt and the associated endophytic fungi

 

Khadiga

Amr

Pharmacy/Ain shams university

Running/MSc

19.

Isolation of bioactive natural products from endophytic fungi associated with Canna Indica family cannaceae

 

Ashrqat

Ismail

Pharmacy/Ain shams university

Running/MSc

A.Ain shams University

1-Bioactive Secondary Metabolites from Plants and their Symbiotic Fungi

B.STDF

1. Drug Discovery of new Anti-infective and Anti-cancer agents
2. Bioactive Metabolites from Marine Endosymbiotic Fungi

Joint Egyptian- Japanese Project

1. Research teams performing different research work mainly focusing on discovery of drug entities either naturally isolated or completely synthetic as well as bioassay evaluation.
2. Applying for different projects from different funding agencies.
3. International cooperation.
Workshops for researchers and students
(undergraduate and postgraduate).

1. Performing different analytical experiments for researchers with cost (25% discount for postgraduate of Faculty of pharmacy - Ain Shams University.
2. Providing consultations for pharmaceutical companies Training and workshops.

E-mail: ddr_d2013@pharma.asu.edu.eg

Address: African Union ST./Abbassia/Cairo/Egypt/11566

Phone: +2 024012466